The rationale for this trial is to demonstrate the feasibility and safety of allogeneic HCT for patients with chemotherapy-sensitive hematological malignancies and coincident HIV-infection. The study aims to develop these devices so as to learn quickly about issues that patients and their caregivers are facing so that clinicans can intervene to stop unnecessary re-hospitalizations in this population. A Study of Evaluating the Use of Ultrasound Shear Wave Imaging in Patients with Liver Fibrosis, A Pilot Study Examining Thiamine Deficiency in Patients Admitted to the Hospital for Liver Transplantation, Increasing Activity in Liver Transplant Patients, Exercise Intervention - and Impact on Hospitalization, Correlation of Hepatic MR Elastography with Histopathology and/or Abdominal MRI in Patients with Chronic Liver Disease and Malignancy, Pulmonary Rehabilitation in End-Stage Liver Disease, A Study of Study of Free-Breathing Magnetic Resonance Elastography (MRE) of the Liver in Healthy Volunteers and Its Longitudinal Application in Patients with Chronic Liver Diseases, A Biorepository of Induced Pluripotent Stem Cells from Subjects with Liver Disease, Bleeding in Hospitalized Patients with Liver Disease, A Study of Short-term Survival in Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%, A Study to Compare the Occurrence of Elevated Liver Enzymes Between Adult Patients Receiving Daily IV Fat Emulsions versus Only Three Times per Week, Primary Cell Lines Derived from the Human Gall Bladder for the Purpose of Gene and Cell Therapy for Metabolic Liver Disorders, Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD), Defibrotide for Patients with Hepatic Veno-occlusive Disease: A Treatment IND Study, A Study to Evaluate Whether or Not Extracellular Counts and Content Can Diagnose Alcoholic Hepatitis, Pharmacogenomics (PGx) Results and Clinical Data of Established Patients with Liver Disease to Assess Current and Future Therapeutic Relevance of PGx Testing, Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 2, A Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 with Terlipressin Treatment, Evaluating the Effectiveness of the Patient Buddy Mobile Health App to Prevent Unavoidable Readmission, Improve HRQOL and Prevent Hospitalizations in Patients with Cirrhosis, A Study of the Frequency of Kidney Stone Formation in Liver Disease Patients, A Study of Extracellular RNA Markers of Liver Disease and Cancer, A Multicenter Open Label Trial Using Ambrisentan in Patients with Porto-pulmonary Hypertension, The Olmsted NAFLD Epidemiology Study (TONES), Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites, A Study of IDN-6556 in Subjects With NAFLD and Raised Transaminases, A Study to Evaluate the Alfapump® System in the Treatment of Refractory or Recurrent Ascites, Randomized Global Phase 3 Study to Evaluate the Impact of Obeticholic Acid Treatment on Nonalcoholic Steatohepatitis Patients, A 5-year Observational Study of Patients With Nonalcoholic Fatty Liver Disease (NAFLD) or Nonalcoholic Steatohepatitis (NASH), Study Investigating the Activity of Vidofludimus Calcium as a Treatment for Primary Sclerosing Cholangitis (PSC), Treating Adult Patients with Primary Sclerosing Cholangitis with Oral Vancomycin in a Randomized Trial, Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure, A Study of the Safety, Tolerability, and Effectiveness of GS-9674 for Adults with Primary Sclerosing Cholangitis without Cirrhosis, Use of F-652 in Patients With Alcoholic Hepatitis, A Study to Evaluate the Safety and Effectiveness of Obeticholic Acid Treatment on People with Non-Alcoholic Steatohepatitis with Fibrosis, A Study to Evaluate the Effectiveness and Safety of CC-90001 in Subjects With Non-alcoholic Steatohepatitis (NASH) and Stage 3 or Stage 4 Liver Fibrosis, A Study to Establish an Alcoholic Hepatitis Network, A Study of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA), A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC), Metabolomics of Portal Venous Blood for the Study of the Gut-liver Axis in Hepatobiliary Disease, A Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir and Dasabuvir in Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis, Study to Evaluate the Safety and Effectiveness of BMS-986036 in Adults with Nonalcoholic Steatophepatitis (NASH) and Stage 3 Liver Fibrosis, A Study to Evaluate the Effectiveness and Safety of Elafibranor for Patients with Nonalcoholic Fatty Liver Disease, A Study to Evaluate Dupilumab as a Treatment for Moderate-to-Severe, Chronic Hepatic Pruritus, A Study to Evaluate the Combining of Endoscopic Ultrasound Guided Liver Biopsy and Stomach Balloon Placement for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease and Obesity, A Study of the Use of a New Drug in People with Non-Alcoholic Steatohepatitis (NASH) or Non-Alcoholic Fatty Liver Disease (NAFLD), Study to Evaluate the Safety and Effectiveness of BMS-986036 in Adults with Nonalcoholic Steatophepatitis (NASH) and Compensated Liver Cirrhosis, A Study to Evaluate Pulmonary Vascular Complications of Liver Disease 3 (PVCLD3), Transforming Non-Invasive Liver Disease Detection by Magnetic Resonance Elastography, Simtuzumab (GS-6624) in the Treatment of Cirrhosis Due to NASH, A Study of the Effectiveness and Safety of Subcutaneous Semaglutide for Patients with Fatty-Liver Disease, not Caused by Alcoholism, A Study to Develop a Resource (bank) of Biospecimens and Data Collected from Individuals with Liver Disease and Without Liver Disease, Safety and Efficacy of Simtuzumab (GS-6624) in Adults With Advanced Liver Fibrosis But Not Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH), Post-transplant NASH Protocol to Assess the Development of Metabolic Co-morbidities and Disease Recurrence in Patients Transplanted for NASH Cirrhosis, A Study to Evaluate Diagnostic Accuracy of the Controlled Attenuation Parameter(CAP) Measured by FibroScan® in Patients Scheduled for a Liver Biopsy, Validation of Cognitive Tests in Elderly Cirrhotic Patients, Dose Response Study of GSK2330672 for the Treatment of Pruritus in Patients With Primary Biliary Cholangitis, A Study of the Effect of Sildenafil for Improvement of Hepatic Fibrosis after the Fontan Heart Surgery, Dissecting the Genetic Environment Contributions of Autoimmune Liver Disease, Allogeneic Transplant in HIV Patients (BMT CTN 0903), Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma, The Circulating Cell-free Genome Atlas Study, A Study to Evaluate the Challenges, Behavioral Patterns, and Preferences of Minority Patient Participation in Clinical Trials, A Study to Evaluate Exercise for Cancer Patients at Risk of Falling, Advertising and sponsorship opportunities. Development and Assessment of The Polycystic Liver Disease Questionnaire (PLD-Q). A Study to Develop a Breath Analysis Test. The American Liver Foundation does not endorse and is not affiliated with any of these trials. TARGET-NASH is a longitudinal observational cohort study of patients being managed for NAFLD or NASH in usual clinical practice. Board of Directors clinical trials for liver disease, new drugs are coming but first they have to finish the trials. 27 in progress, 9 open to eligible people . The purpose of this study is to investigate the potential effectiveness of dupilumab in the treatment of moderate-to-severe, chronic hepatic pruritus. Phase 2a, dose-ranging Study with PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD). Clinical Trials for NAFLD & NASH The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other components of the National Institutes of Health (NIH) conduct and support … However, milder forms of alcoholic hepatitis often do not cause any symptoms. This study will evaluate whether simtuzumab (formerly referred to as GS-6624) is effective at preventing the histologic progression of liver fibrosis and the clinical progression to cirrhosis in participants with … A variety of liver insults lead to pathological changes in liver architecture that culminate in cirrhosis. Health & Wellness Filter this list of studies by location, status and more. document.querySelector('.in-your-area-dropdown').addEventListener('change', function(e) { Inova Clinical Trials Team. The purpose of this study is toexamine whether increased sphingosine 1 phosphate : ceramide ratio and circulating bile acids are associated with HPS in patients with advanced liver disease. Clinical trials are research studies that test how well new medical approaches work in people. The purpose of this study is to evaluate the safety, tolerability, and effectiveness of GS-9674 in adults who have primary sclerosing cholangitis. This study is being conducted to evaluate the efficacy, safety and tolerability of GSK2330672 administration for the treatment of pruritus (itch) in participants with primary biliary cholangitis (PBC). All trials on the list are supported by NCI. Participants will be treated with either placebo or one of the 4 dose regimens of GSK2330672 (20 milligram [mg], 90 mg or 180 mg taken once daily or 90 mg twice daily). Each phase of a clinical trial has a different purpose. The purpose of this study is to report the proportion of thiamine deficiency (as defined by the Mayo Clinic Laboratory reference range) in liver transplant patients. The purpose of this study is to evaluate the safety and effectiveness of seladelpar in subjects with primary biliary cholangitis (PBC) and an inadequate response to or intolerance to ursodeoxycholic acid (UDCA). The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in … Speak with your doctor about the ongoing progress and results of these trials to get the most up-to-date information on new treatments. The goal of this study is to examine the current and (potential) future therapeutic relevance of PGx testing in established patients with liver disease seen in the Division of Gastroenterology/Hepatology, in order to improve patient clinical care at Mayo Clinic with more effective and efficient prescribing of medications. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US. The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. What are clinical trials for NAFLD and NASH? The purpose of this study is to demonstrate the safety and effectiveness of BMS-986036.in participants with NASH and stage 3 liver fibrosis. In addition to helping others, you get extra care and monitoring from the clinical trials staff and may receive the newest treatments for a disease. This study will evaluate whether simtuzumab (formerly referred to as GS-6624) is effective at preventing the histologic progression of liver fibrosis and the clinical progression to cirrhosis in participants with non-alcoholic steatohepatitis (NASH). GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses. This study is to evaluate the safety and efficacy of simtuzumab (GS-6624) in adults with compensated cirrhosis due to Non-Alcoholic Steatohepatitis (NASH). Mayo Clinic does not endorse any of the third party products and services advertised. © 1998-2021 Mayo Foundation for Medical Education and Research. Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. The treatment may be a pharmaceutical drug, genetic therapy, natural health product, medical device, psychotherapy, or even a lifestyle and preventive care intervention. This phase II trial studies how well temsirolimus and bevacizumab work in treating patients with advanced endometrial, ovarian, liver, carcinoid, or islet cell cancer. Medical Advisory Committee var selectedItem = sessionStorage.getItem("SelectedItem"); This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis (PSC). Additionally, this research study will be used to try to discover new therapies for treating liver disease using gallbladder cells. As a patient at Cedars-Sinai, you will have access to the latest clinical trials and research for hepatology. Clinical trials are used for all types and stages of liver cancer. Clinical trials look at new ways to prevent, detect, or treat disease. ALF Online Support Groups A variety of NASH clinical trials have attempted to find new treatment options. Medical Terminology, WEBSITE FEEDBACK Liver Cancer clinical trials at UCSF . In this study, researchers aim to measure and evaluate changes in the intestines and throughout the entire body of patients with liver cirrhosis by collecting tissue and fluid samples from the small … The purpose of this study is to compare the incidence and frequency of elevated liver enzymes or parenteral (IV) nutrition-associated liver disease, in adult patients who are receiving daily versus three time per week soybean based intravenus (IV) fat emulsions. Liver Disease Clinical Trials A listing of Liver Disease medical research trials actively recruiting patient volunteers. The purpose of this study is to assess the impact of a formal home based video strengthening program (REST) on sarcopenia and frailty. This is a research trial testing DUR-928 (an experimental medication). Phase 2. The purpose of this study is to determine if there are differences in the metabolites (enzymes and other proteins) found in portal venous blood (blood in the portal vein, which delivers blood from the intestines to the liver), peripheral venous blood, and bile between individuals with liver disease undergoing liver transplantation and healthy donors. The Betty and Guy Beatty Center for Integrated Research conducts clinical trials of new medications for the treatment of liver disease. Therefore, the primary endpoints for this study will include 6 minute walk distance (6MWD) and pulmonary vascular resistance (PVR). Many focus on new treatments to learn if a new treatment is safe, effective, and possibly better than the existing treatments. The Progression of Liver Disease Cancer clinical trials determine if a treatment shows an improved way of caring for patients. The total duration of a subject's participation will be up to 45 days of screening and 24 weeks of study including follow-up. Clinical Trials for Liver Transplant The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other components of the National Institutes of Health (NIH) conduct and support research into many diseases and conditions. Clinical trials are conducted in a series of steps or phases. The Outpatient Research Clinic is located on the third floor of the Claude Moore Health Education and Research Center building on the Inova Fairfax Medical Campus. Liver Research and Clinical Trials Northwestern Memorial, Chicago, IL As a premier academic medical center, Northwestern Memorial and its collaborative partner Northwestern University Feinberg School of Medicine are committed to the advancement of healthcare through clinical innovation, medical education and scientific research. Backed by a respected team of specialists and researchers, our clinical trials aim to further the advancement of diagnosing and treating your hepatology condition. Subjects on GSK2330672 will also receive placebo tablets to maintain blinding. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or single patient named use). The study population will consist of subjects being discharged after hospitalization for acute decompensation of liver cirrhosis with ascites (or with prior history of ascites requiring diuretic therapy) with or without acute-on-chronic liver failure (ACLF) at admission or during hospitalization but without ACLF at discharge. Below are current clinical trials. In particular, the trial will focus on the 100-day non-relapse mortality as an indicator of the safety of transplant in this patient population. Results from clinical trials of milk thistle for liver diseases have been conflicting or haven’t been clinically meaningful. This research is being done to develop stem cells from cells within patients’ skin. Liver Research and Clinical Trials Northwestern Memorial, Chicago, IL As a premier academic medical center, Northwestern Memorial and its collaborative partner Northwestern University Feinberg School … The most promising treatments are then moved into clinical trials, with the goal of identifying new ways to safely and effectively prevent, screen for, diagnose, or treat a disease. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. This is an Open Label, Multicenter, pilot clinical trial to assess the efficacy and safety of an oral selective Endothelin Receptor Antagonist (ambrisentan) in patients with portopulmonary hypertension. We purpose of this study is to evaluate the diagnosis accuracy of the Controlled Attenuation Parameter (CAP) measured by FibroScan® (both with M and XL probes) in all patients who are undergoing liver biopsy for any liver disease. The primary purpose of this study is to develop an understanding of the prevalence, characteristics, and outcomes of major bleeding and clinically relevant non-maor bleeding in hospitalized patients with cirrhosis undergoing invasive procedures. This research study will help us to improve our understanding of normal liver and gallbladder function. Thank you for expressing your interest in participating in one of our clinical trials. Clinical trials are part of clinical research and at the heart of all medical advances. 4 weeks after starting treatment they will have a repeat full evaluation with imaging tests, blood work, and liver and fat biopsies. Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses. Clinical trials improve cancer care for all. Liver and fatty tissue biopsy Two weeks after the tests, participants will start vitamin E treatment. 14 studies in Liver Transplant Program (open studies only). The purpose of the trial is to assess whether treatment with DUR-928 has any effect on the treatment of Primary Sclerosing Cholangitis (PSC). The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer. The primary objectives of this study are to evaluate the effect of Obeticholic Acid treatment compared to placebo on 1) histological improvement and 2) liver-related clinical outcomes in patients with non-cirrhotic nonalcoholic steatohepatitis (NASH) with liver fibrosis. They will take up to two pills a day, taken with fat-containing foods. sessionStorage.setItem("SelectedItem", this.value); Searching strategies yielded 74 clinical trials: 17 randomized controlled trials, 5 case control and 52 cohort studies. Mon-Fri 9am – 5pm EST. The goal of therapy for these patients is to improve symptoms of dyspnea and to improve pulmonary hemodynamics to a mean pulmonary artery pressure <35 mm Hg in order to make patients eligible for liver transplantation. Contact Us, READ, WATCH, LISTEN Studies have also shown that caspase cleaved cytokeratin 18 is generally elevated to an even greater degree in cirrhosis than in other liver … With this information, we may be able to better understand the importance and nature of the relationship between the gut (i.e. RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of cancer cells by blocking blood flow to the cancer. It is common in patients with autosomal dominant polycystic liver disease (ADPLD) and autosomal dominant polycystic kidney disease (ADPKD). Diagnosing Liver Disease – Liver Biopsy and Liver Function Tests, Glycogen Storage Disease Type 1 (von Gierke), Intrahepatic Cholestasis of Pregnancy (ICP), Progressive Familial Intrahepatic Cholestasis (PFIC), Spread the Word/Become an ALF Social Media Advocate, On the next screen, enter the name of the liver disease and answer specific demographic data (such as city / distance / age). Select one of the following links to see our open clinical trials: Hepatitis C Cirrhosis Fatty Liver – NASH PBC – Primary Biliary Cholangitis Alpha-1 Antitrypsin Deficiency (AATD) Financials & Annual Report Liver Cancer Clinical Trials Clinical trials are research studies that involve people. All ages Under 18 Over 18. Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Clinical, radiological, or biochemical evidence of liver cirrhosis Model for End-Stage Liver Disease (MELD) Score of 11 to 18 during the Screening period Willingness to utilize two reliable forms of contraception (for both males and females of childbearing potential) from Screening to one month after the last dose of study drug. Because it is a silent disease (without symptoms until end stage) and the lab tests can be normal, it can be missed in early stages. The overall objective of this proposal is to conduct a systematic approach to dissect both genetic underpinnings and non-genetic factors in the development of adult autoimmune liver diseases including autoimmune hepatitis (AIH), overlap AIH with Primary Biliary Cirrhosis (AIH-PBC), overlap AIH with Primary Sclerosing Cholangitis (AIH-PSC), and drug-induced autoimmune-like hepatitis (DIAIH). Fatty Liver Clinical Research. Will adult liver transplant patients who are provided with physical activity (walking) instructions increase their physical activity and perceive an improved quality of life? The purpose of this study is to facilitate discovery and development of novel biomarkers of risk and early detection, etiologic factors relating to liver disease, and novel targeted therapeutic and chemopreventive strategies for liver disease such as PSC, PBC, PLD, NAFLD, NASH, ASH, HCC, donors (non-diseased and diseased) for liver transplant or non-liver diseased subjects scheduled for surgery will serve as controls. Report includes an overview of trial numbers and their average enrollment… The first double-blind 72-week treatment period will assess the efficacy and safety of elafibranor on the resolution of NASH without worsening of fibrosis at the intermediate efficacy analysis, followed by a Long-term Treatment Period to assess efficacy on all-cause mortality and liver-related clinical outcomes as measured by the time to first occurrence of any of the listed adjudicated events (all-cause mortality, progression to histological cirrhosis, and the full list of portal hypertension/cirrhosis related events). if(selectedItem) { This study is being done to better understand the relationship between inflammation in your AT, abnormal deposition of fat around your liver and how this affects its appearance and function and ultimately insulin resistance. Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN, Mankato, MN; Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN, Jacksonville, FL; Scottsdale/Phoenix, AZ; Rochester, MN. This Pilot study will enable development & assessment of a Polycystic Liver Disease-specific patient reported outcomes questionnaire (PLD-Q). PURPOSE: This phase I/II trial is studying the side effects and best dose of giving everolimus and lenalidomide together and to see how well they work in treating patients with relapsed or refractory non-Hodgkin or Hodgkin lymphoma. Search for closest city to find more detailed information on a research study in your area. Media Center Drug: IDN-6556 Drug: Placebo. The goal of this study is to examine the current and (potential) future therapeutic relevance of PGx testing in established patients with liver disease seen in the Division of Gastroenterology/Hepatology, in order to improve patient clinical care at Mayo Clinic with more effective and efficient prescribing of medications. Showing trials for . document.querySelector('.in-your-area-dropdown').value = selectedItem; Please ensure to provide your accurate contact information below. clinical trials for liver disease, new drugs are coming but first they have to finish the trials. Liver Cirrhosis Hepatic Cirrhosis. The stem cells will later be converted to liver cells and used to better understand liver disease and help develop treatments. Education and research for hepatology of tumor cells by blocking blood flow to the Terms and Conditions Privacy! Often do not cause any symptoms HCC has increased in recent years many reasons or friends deciding! 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